Dissociation of ERMES clusters plays a key role in attenuating the endoplasmic reticulum stress.

ABSTRACT: In yeast, ERMES, which mediates phospholipid transport between the ER and mitochondria, forms a limited number of oligomeric clusters at ER-mitochondria contact sites in a cell. Although the number of the ERMES clusters appears to be regulated to maintain proper inter-organelle phospholipid trafficking, its underlying mechanism and physiological relevance remain poorly understood. Here, we show that mitochondrial dynamics control the number of ERMES clusters. Moreover, we find that ER stress causes dissociation of the ERMES clusters independently of Ire1 and Hac1, canonical ER-stress response pathway components, leading to a delay in the phospholipid transport from the ER to mitochondria. Our biochemical and genetic analyses strongly suggest that the impaired phospholipid transport contrib

SUBMITTER: Kakimoto-Takeda Y 

PROVIDER: S-EPMC9626684 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature