Targeting PTEN but not SOCS3 resists an age-dependent decline in promoting axon sprouting.

ABSTRACT: Axonal repair is critical for functional recovery after injury of the CNS. We previously reported that neuronal PTEN deletion exhibits an age-dependent decline in promoting axon regeneration from the corticospinal tract (CST). How sprouting of uninjured axons, a naturally occurring form of axonal repair, is impacted by age is unknown. We assessed CST sprouting after unilateral pyramidotomy in PTEN and/or SOCS3-deleted mice at different ages. While PTEN deletion enhances sprouting independently of age, SOCS3 deletion loses its sprouting-promoting effect with age. The synergistic effect of PTEN/SOCS3 co-deletion on CST sprouting is rapidly lost with increased age. Overall, promoting sprouting appears more robust across age than regeneration, y

SUBMITTER: Geoffroy CG 

PROVIDER: S-EPMC9626739 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature