Identification of the common differentially expressed genes and pathogenesis between neuropathic pain and aging.

ABSTRACT:

Background

Neuropathic pain is a debilitating disease caused by damage or diseases of the somatosensory nervous system. Previous research has indicated potential associations between neuropathic pain and aging. However, the mechanisms by which they are interconnected remain unclear. In this study, we aim to identify the common differentially expressed genes (co-DEGs) between neuropathic pain and aging through integrated bioinformatics methods and further explore the underlying molecular mechanisms.

Methods

The microarray datasets GSE24982, GSE63442, and GSE63651 were downloaded from Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) and co-DEGs were first identified. Functional enrichment analyses, protein-protein Interaction (PPI) network, module

SUBMITTER: Ye Q 

PROVIDER: S-EPMC9626798 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature