Intratracheal inoculation results in Brucella-associated reproductive disease in male mouse and guinea pig models of infection.

ABSTRACT: Brucella species are considered a significant cause of reproductive pathology in male and female animals. Importantly, Brucella melitensis can induce reproductive disease in humans. Reproductive pathogenesis and evaluation of newly developed countermeasures against brucellosis studies have traditionally utilized female animal models. However, any potential, new intervention for use in humans would need to be evaluated in both sexes. Therefore, animal models for male reproductive brucellosis are desperately needed to understand disease progression. Accordingly, we evaluated guinea pigs and mice using B. melitensis 16 M in an intratracheal model of inoculation at different stages of infection (peracute, acute, and chronic) with an emphasis on determining the effect to th

SUBMITTER: Hensel ME 

PROVIDER: S-EPMC9626965 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature