A new approach to delineating clinical target volume for radiotherapy of glioblastoma: A phase II trial.

ABSTRACT:

Purpose

No consensus has currently been reached regarding the optimal radiation volume for radiotherapy of glioblastoma. Here, we have proposed a new delineation approach to delineating clinical target volume based on the relationship between the growth patterns of glioblastoma and neural pathways. Its safety and efficacy were evaluated in a phase II clinical trial.

Methods

A total of 69 patients with histologically confirmed glioblastoma were enrolled. All patients underwent tumor resection, followed by focal radiotherapy and concomitant temozolomide (TMZ), and then received six cycles of adjuvant TMZ. The gross tumor volume (GTV) was defined as the surgical resection cavity plus any residual enhancing tumor, on contrast enhanced T1-weighted MRI. The clinical target volume

SUBMITTER: Huang Y 

PROVIDER: S-EPMC9626993 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature