Feasibility of avian antibodies as prophylaxis against enterotoxigenic escherichia coli colonization.

ABSTRACT:

Background

This research aims to evaluate the feasibility of using avian immunoglobulins (IgY) raised against adhesion factors of enterotoxigenic Escherichia coli (ETEC) as prophylaxis of diarrheal illness caused by these pathogens. ETEC requires adhesion to human intestinal epithelial cells as a primary step in establishing enteric infection. Therefore, inhibition of adhesion may prevent such infections and reduce clinical burdens of diarrheal illness.

Methods

IgY samples were prepared from eggs of hens immunized with an adhesin-tip multiepitope fusion antigen (MEFA), developed against nine adhesin tip epitopes derived from clinically relevant ETEC strains. The resulting IgY was evaluated for its ability to inhibit adhesion of ETEC to cell-surface targets. Potential

SUBMITTER: Brumfield K 

PROVIDER: S-EPMC9627289 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature