Connectivity of corticostriatal circuits in nonmanifesting LRRK2 G2385R and R1628P carriers.

ABSTRACT:

Background

Neuroimaging studies have shown that the functional connectivity (FC) of corticostriatal circuits in nonmanifesting leucine-rich repeat kinase 2 (LRRK2) G2019S mutation carriers mirrors neural changes in idiopathic Parkinson's disease (PD). In contrast, neural network changes in LRRK2 G2385R and R1628P mutations are unclear. We aimed to investigate the FC of corticostriatal circuits in nonmanifesting LRRK2 G2385R and R1628P mutation carriers (NMCs).

Methods

Twenty-three NMCs, 28 PD patients, and 29 nonmanifesting noncarriers (NMNCs) were recruited. LRRK2 mutation analysis was performed on all participants. Clinical evaluation included MDS-UPDRS.

Results

When compared to NMNCs, NMCs showed significantly reduced FC between the caudate nucleus and superior fro

SUBMITTER: Zhang D 

PROVIDER: S-EPMC9627388 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature