5-Fluorouracil reduces the fibrotic scar via inhibiting matrix metalloproteinase 9 and stabilizing microtubules after spinal cord injury.

ABSTRACT:

Aims

Fibrotic scars composed of a dense extracellular matrix are the major obstacles for axonal regeneration. Previous studies have reported that antitumor drugs promote neurofunctional recovery.

Methods

We investigated the effects of 5-fluorouracil (5-FU), a classical antitumor drug with a high therapeutic index, on fibrotic scar formation, axonal regeneration, and functional recovery after spinal cord injury (SCI).

Results

5-FU administration after hemisection SCI improved hind limb sensorimotor function of the ipsilateral hind paws. 5-FU application also significantly reduced the fibrotic scar formation labeled with aggrecan and fibronectin-positive components, Iba1⁺ /CD11b⁺ macrophages/microglia, vimentin, chondroitin sulfate proteoglycan 4 (

SUBMITTER: Xu Y 

PROVIDER: S-EPMC9627390 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature