Association of Hormone Therapy With Depression During Menopause in a Cohort of Danish Women.

ABSTRACT:

Importance

During menopause, the levels of estrogen and progesterone decrease and 60% to 70% of women experience menopausal symptoms, including mood disturbances. The latter might be prevented by hormone therapy (HT), yet some studies have suggested that use of HT might be associated with increased risk of depression.

Objective

To examine whether use of HT during menopause was associated with a subsequent diagnosis of depression.

Design, setting, and participants

This nationwide register-based cohort and self-controlled case series study included all women in Denmark aged 45 years between January 1, 1995, through December 31, 2017 (n = 825 238), without prior oophorectomy, breast cancer, or cancer in reproductive organs. Follow-up was completed on December 31, 2018. T

SUBMITTER: Wium-Andersen MK 

PROVIDER: S-EPMC9627415 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature