Receptor of advanced glycation end-products axis and gallbladder cancer: A forgotten connection that we should reconsider.

ABSTRACT: Compelling evidence derived from clinical and experimental research has demonstrated the crucial contribution of chronic inflammation in the development of neoplasms, including gallbladder cancer. In this regard, data derived from clinical and experimental studies have demonstrated that the receptor of advanced glycation end-products (RAGE)/AGEs axis plays an important role in the onset of a crucial and long-lasting inflammatory milieu, thus supporting tumor growth and development. AGEs are formed in biological systems or foods, and food-derived AGEs, also known as dietary AGEs are known to contribute to the systemic pool of AGEs. Once they bind to RAGE, the activation of multiple and crucial signaling pathways are triggered, thus favoring the secretion of several proinflammatory cytokines

SUBMITTER: Rojas A 

PROVIDER: S-EPMC9627425 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature