A critical analysis of the current TNM classification for differentiated thyroid carcinoma in young patients: Time for a change?

ABSTRACT:

Background

The current TNM classification that simply classifies differentiated thyroid carcinoma (DTC) patients younger than 55 years into stage I and stage II based on the presence or absence of distant metastases has been questioned. In this study, we reexamined the impact of T status and N status on prognosis and then developed a new prediction model to improve the predictability of cancer-specific survival (CSS) in young patients.

Materials and methods

Kaplan-Meier method was applied to calculate the CSS. Multivariable Cox proportional hazards models were used to assess the impact of T status and N status on CSS after adjustment for known covariates. The area under the receiver operating characteristic curve (AUC), C-index, Bayesian information criterion (BIC), and Akai

SUBMITTER: Wang W 

PROVIDER: S-EPMC9627501 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature