Midlife determinants of healthy cardiovascular aging: The Atherosclerosis Risk in Communities (ARIC) study.

ABSTRACT:

Background and aims

Risk factor cutoffs are derived from associations with clinical cardiovascular disease (CVD), but how these risk factors associate with preserved cardiovascular health into old age is not well studied. We investigated midlife determinants of healthy versus nonhealthy cardiovascular aging in the Atherosclerosis Risk in Communities (ARIC) study.

Methods

ARIC participants were categorized by cardiovascular status in older age (mean age 75.8 ± 5.3 years, range 66-90): healthy, subclinical disease (assessed by biomarkers and left ventricular function), clinical CVD (coronary heart disease, stroke, or heart failure), or prior death. We examined associations of midlife (mean age 52.1 ± 5.1 years) systolic and diastolic blood pressure (SBP, DBP), low-density lipo

SUBMITTER: Jia X 

PROVIDER: S-EPMC9627572 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature