Retrospective cohort study to assess the association between treatment with tocilizumab and mortality among mechanically ventilated patients with COVID-19.

ABSTRACT:

Objectives

Assess the association between tocilizumab administration and clinical outcomes among mechanically ventilated patients with COVID-19 pneumonia.

Design

Retrospective cohort study.

Setting

Large integrated health system with 9 million members in California, USA.

Participants

4185 Kaiser Permanente members hospitalised with COVID-19 pneumonia requiring invasive mechanical ventilation (IMV).

Interventions

Receipt of tocilizumab within 10 days of initiation of IMV.

Outcome measures

Using a retrospective cohort of consecutive patients hospitalised with COVID-19 pneumonia who required IMV in a large integrated health system in California, USA, we assessed the association between tocilizumab administration and 28-day mortality, time to extubati

SUBMITTER: Skarbinski J 

PROVIDER: S-EPMC9627573 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature