Normal aging in mice is associated with a global reduction in cortical spectral power and network-specific declines in functional connectivity.

ABSTRACT: Normal aging is associated with a variety of neurologic changes including declines in cognition, memory, and motor activity. These declines correlate with neuronal changes in synaptic structure and function. Degradation of brain network activity and connectivity represents a likely mediator of age-related functional deterioration resulting from these neuronal changes. Human studies have demonstrated both general decreases in spontaneous cortical activity and disruption of cortical networks with aging. Current techniques used to study cerebral network activity are hampered either by limited spatial resolution (e.g. electroencephalography, EEG) or limited temporal resolution (e.g., functional magnetic resonance imaging, fMRI). Here we utilize mesoscale imaging of neuronal activity in Thy1-GC

SUBMITTER: Albertson AJ 

PROVIDER: S-EPMC9627742 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature