Circulating Furin-Cleaved Proprotein Convertase Subtilisin/Kexin Type 9 Concentration Predicts Future Coronary Events in Japanese Subjects.

ABSTRACT:

Background

Proprotein convertase subtilisin/kexin type 9 (PCSK9) circulates as mature and furin-cleaved forms, which differ in their properties to degrade low-density lipoprotein (LDL) receptors.

Objectives

In this study, we sought to investigate whether PCSK9 subtypes associate with atherosclerotic cardiovascular events.

Methods

We investigated 1,436 statin-naive Japanese subjects without any cardiovascular disease in the Suita Study, an epidemiologic Japanese cohort study. Total, mature, and furin-cleaved PCSK9 levels were measured by means of enzyme-linked immunosorbent assay. The occurrence of coronary and stroke events were compared in subjects stratified by PCSK9 level tertile.

Results

Total, mature, and furin-cleaved PCSK9 levels were associated with non

SUBMITTER: Kataoka Y 

PROVIDER: S-EPMC9627806 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature