S-EPMC9627907 - Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels. - OmicsDI

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Dataset Information

Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels.

ABSTRACT:

Background

Despite a potential role of hemoglobin in atherosclerosis, data on coronary plaque volume changes (PVC) related to serum hemoglobin levels are limited.

Objectives

The authors sought to evaluate coronary atherosclerotic plaque burden changes related to serum hemoglobin levels using serial coronary computed tomographic angiography (CCTA).

Methods

A total of 830 subjects (age 61 ± 10 years, 51.9% male) who underwent serial CCTA were analyzed. The median interscan period was 3.2 (IQR: 2.5-4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were stratified into 4 groups based on the quartile of baseline hemoglobin levels. Annualized total PVC (mm³/year) was defined as total PVC divided by the interscan period.

Results

Baseline total plaque volume (mm³) was not different among all groups (group I [lowest]: 34.1 [IQR: 0.0-127.4] vs group II: 28.8 [IQR: 0.0-123.0] vs group III: 49.9 [IQR: 5.6-135.0] vs group IV [highest]: 34.3 [IQR: 0.0-130.7]; P = 0.235). During follow-up, serum hemoglobin level changes (Δ hemoglobin; per 1 g/dL) was related to annualized total PVC (β = -0.114) in overall participants (P < 0.05). After adjusting for age, sex, traditional risk factors, baseline hemoglobin and creatinine levels, baseline total plaque volume, and the use of aspirin, beta-blocker, angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, and statin, Δ hemoglobin significantly affected annualized total PVC in only the composite of groups I and II (β = -2.401; P = 0.004).

Conclusions

Serial CCTA findings suggest that Δ hemoglobin has an independent effect on coronary atherosclerosis. This effect might be influenced by baseline hemoglobin levels. (Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging [PARADIGM]; NCT02803411).

SUBMITTER: Won KB

PROVIDER: S-EPMC9627907 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Publications

Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels.

Won Ki-Bum KB Lee Byoung Kwon BK Heo Ran R Park Hyung-Bok HB Lin Fay Y FY Hadamitzky Martin M Kim Yong-Jin YJ Sung Ji Min JM Conte Edoardo E Andreini Daniele D Pontone Gianluca G Budoff Matthew J MJ Gottlieb Ilan I Chun Eun Ju EJ Cademartiri Filippo F Maffei Erica E Marques Hugo H de Araújo Gonçalves Pedro P Leipsic Jonathon A JA Lee Sang-Eun SE Shin Sanghoon S Choi Jung Hyun JH Virmani Renu R Samady Habib H Chinnaiyan Kavitha K Berman Daniel S DS Narula Jagat J Bax Jeroen J JJ Min James K JK Chang Hyuk-Jae HJ

JACC. Asia 20220412 3

<h4>Background</h4>Despite a potential role of hemoglobin in atherosclerosis, data on coronary plaque volume changes (PVC) related to serum hemoglobin levels are limited.<h4>Objectives</h4>The authors sought to evaluate coronary atherosclerotic plaque burden changes related to serum hemoglobin levels using serial coronary computed tomographic angiography (CCTA).<h4>Methods</h4>A total of 830 subjects (age 61 ± 10 years, 51.9% male) who underwent serial CCTA were analyzed. The median interscan pe ...[more]

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