Ageing-resembling phenotype of long-term allogeneic hematopoietic cells recipients compared to their donors.

ABSTRACT:

Background

Ageing is a complex phenomenon that leads to decreased proliferative activity, loss of function of the cells, and cellular senescence. Senescence of the immune system exacerbates individual's immune response, both humoral and cellular but increases the frequency of infections. We hypothesized that physiological ageing of adaptive immune system occurs in recipients of allogeneic hematopoietic cells transplant (allo-HCT) at faster rate when compared to their respective donors since the small number of donor cells undergo immense proliferative stress restoring recipients hematopoiesis. We compared molecular characterizations of ageing between recipients and donors of allo-HCT: telomeric length and immunophenotypic changes in main lymphocyte subsets - CD4⁺, CD8

SUBMITTER: Czarnogorski MC 

PROVIDER: S-EPMC9628063 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature