Differentially hypomethylated cell-free DNA and coronary collateral circulation.

ABSTRACT:

Background

The factors affecting cardioprotective collateral circulation are still incompletely understood. Recently, characteristics, such as CpG methylation of cell-free DNA (cfDNA), have been reported as markers with clinical utility. The aim of this study was to evaluate whether cfDNA methylation patterns are associated with the grade of coronary collateral circulation (CCC).

Result

In this case-control study, clinical and angiographic data were obtained from 143 patients (mean age, 58 years, male 71%) with chronic total coronary occlusion. Enzymatic methyl-sequencing (EM-seq) libraries were prepared using the cfDNA extracted from the plasma. Data were processed to obtain the average methylation fraction (AMF) tables of genomic regions from which blacklisted regions were

SUBMITTER: Ahn J 

PROVIDER: S-EPMC9628091 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature