Current clinical practice for familial adenomatous polyposis in Japan: A nationwide multicenter study.

ABSTRACT:

Introduction

In Japanese patients with familial adenomatous polyposis (FAP), colectomy tends to be postponed or avoided.

Aim

This study aimed to clarify the current clinical practice from a Japanese multicenter cohort study database.

Methods

We analyzed the records of 250 patients with non-dense FAP who did not require colorectal cancer removal. The clinical outcomes were compared between patients who received colectomy (n = 142) (Group A) and those who did not receive colectomy (n = 108) (Group B).

Results

The colectomy rate based on the age at the final follow-up examination was 46%, 60%, 54%, 65%, at ≤29, 30-39, 40-49, and ≥ 50 years, respectively (P = .11). The development of colorectal cancer did not differ between Groups A and B (25% vs 22% P

SUBMITTER: Matsubara T 

PROVIDER: S-EPMC9628228 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature