Longer Time Interval from Neoadjuvant Chemoradiation to Surgery is Associated with Poor Survival for Patients Without Clinical Complete Response in Oesophageal Cancer.

ABSTRACT:

Background

The optimal interval between neoadjuvant therapy and oesophagectomy for oesophageal cancer remains controversial.

Methods

Patients with locally advanced oesophageal squamous cell carcinoma (ESCC) who received neoadjuvant chemoradiotherapy followed by oesophagectomy between June 2017 and December 2020 were prospectively enrolled and retrospectively analysed. Patients were divided into two groups: timely (group A; < 10 weeks) and delayed (group B; ≥ 10 weeks) surgery groups. Survival was the primary outcome, and tumour response and post-operative complications were the secondary outcomes.

Results

Overall, 224 patients were recruited; 116 patients (51.8%) underwent timely surgery within 10 weeks (group A), and 108 patients (49.2%) underwent delayed surgery ove

SUBMITTER: Xiao X 

PROVIDER: S-EPMC9628481 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature