Developing an Exposure Burden Score for Chemical Mixtures Using Item Response Theory, with Applications to PFAS Mixtures

ABSTRACT:

Background:

There are few existing methods to quantify total exposure burden to chemical mixtures, independent of a health outcome. A summary metric could be advantageous for use in biomonitoring, risk assessment, health risk calculators, and mediation models.

Objective:

We developed a novel exposure burden score method for chemical mixtures, applied it to estimate exposure burden to per- and polyfluoroalkyl substances (PFAS) mixtures, and estimated associations of PFAS burden scores with cardio-metabolic outcomes in the general U.S. population.

Methods:

We applied item response theory (IRT) to biomonitoring data from 1,915 children and adults 12–80 years of age in the 2017–2018 National Health and Examination Survey to quantify a latent PFAS burden score, using serum concentrations of eight measured PFAS biomarkers, each considered an “item.” The premise of IRT is that through using both information about a participant’s concentration of an individual PFAS biomarker, as well as their exposure patterns for the PFAS mixture, we can estimate the participant’s latent PFAS exposure burden, independent of a health outcome. We used linear regression to estimate associations of the PFAS burden score with cardio-metabolic outcomes and compared our findings to results using summed PFAS concentrations as the exposure metric.

Results:

PFAS burden scores and summed PFAS concentrations had moderate-high correlation (

Discussion:

IRT offers a straightforward way to include exposure biomarkers with low detection frequencies and can reduce exposure measurement error. Further, IRT enables comparisons of exposure burden to chemical mixtures across studies even if they did not measure the exact same set of chemicals, which supports harmonization across studies and consortia. We provide an accompanying PFAS burden calculator (https://pfasburden.shinyapps.io/app_pfas_burden/), enabling researchers to calculate PFAS burden scores based on U.S. population exposure reference ranges. https://doi.org/10.1289/EHP10125

SUBMITTER: Liu S 

PROVIDER: S-EPMC9628675 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature