Cognitive Outcomes in the Pragmatic Investigation of optimaL Oxygen Targets (CO-PILOT) trial: protocol and statistical analysis plan.

ABSTRACT:

Introduction

Long-term cognitive impairment is one of the most common complications of critical illness among survivors who receive mechanical ventilation. Recommended oxygen targets during mechanical ventilation vary among international guidelines. Different oxygen targets during mechanical ventilation have the potential to alter long-term cognitive function due to cerebral hypoxemia or hyperoxemia. Whether higher, intermediate or lower SpO₂ targets are associated with better cognitive function at 12-month follow-up is unknown.

Methods and analysis

The Pragmatic Investigation of optimaL Oxygen Targets (PILOT) trial is an ongoing pragmatic, cluster-randomised, cluster-crossover trial comparing the effect of a higher SpO₂ targ

SUBMITTER: Mart MF 

PROVIDER: S-EPMC9628689 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature