Dataset Information

Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin α_vβ₅ Axis.

ABSTRACT: Zika virus (ZIKV) causes microcephaly by killing neural precursor cells (NPCs) and other brain cells. ZIKV also displays therapeutic oncolytic activity against glioblastoma (GBM) stem cells (GSCs). Here we demonstrate that ZIKV preferentially infected and killed GSCs and stem-like cells in medulloblastoma and ependymoma in a SOX2-dependent manner. Targeting SOX2 severely attenuated ZIKV infection, in contrast to AXL. As mechanisms of SOX2-mediated ZIKV infection, we identified inverse expression of antiviral interferon response genes (ISGs) and positive correlation with integrin α_v (ITGAV). ZIKV infection was disrupted by genetic targeting of ITGAV or its binding partner ITGB5 and by an antibody specific for integrin α_vβ₅. ZIKV selectively eliminated GSCs from species-matched human mature cerebral organoids and GBM surgical specimens, which was reversed by integrin α_vβ₅ inhibition. Collectively, our studies identify integrin α_vβ₅ as a functional cancer stem cell marker essential for GBM maintenance and ZIKV infection, providing potential brain tumor therapy.

SUBMITTER: Zhu Z

PROVIDER: S-EPMC9628766 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin α<sub>v</sub>β<sub>5</sub> Axis.

Zhu Zhe Z Mesci Pinar P Bernatchez Jean A JA Gimple Ryan C RC Wang Xiuxing X Schafer Simon T ST Wettersten Hiromi I HI Beck Sungjun S Clark Alex E AE Wu Qiulian Q Prager Briana C BC Kim Leo J Y LJY Dhanwani Rekha R Sharma Sonia S Garancher Alexandra A Weis Sara M SM Mack Stephen C SC Negraes Priscilla D PD Trujillo Cleber A CA Penalva Luiz O LO Feng Jing J Lan Zhou Z Zhang Rong R Wessel Alex W AW Dhawan Sanjay S Diamond Michael S MS Chen Clark C CC Wechsler-Reya Robert J RJ Gage Fred H FH Hu Hongzhen H Siqueira-Neto Jair L JL Muotri Alysson R AR Cheresh David A DA Rich Jeremy N JN

Cell stem cell 20200116 2

Zika virus (ZIKV) causes microcephaly by killing neural precursor cells (NPCs) and other brain cells. ZIKV also displays therapeutic oncolytic activity against glioblastoma (GBM) stem cells (GSCs). Here we demonstrate that ZIKV preferentially infected and killed GSCs and stem-like cells in medulloblastoma and ependymoma in a SOX2-dependent manner. Targeting SOX2 severely attenuated ZIKV infection, in contrast to AXL. As mechanisms of SOX2-mediated ZIKV infection, we identified inverse expression ...[more]

PMID: 31956038

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Dataset Information

Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin α_vβ₅ Axis.

Publications

Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin α<sub>v</sub>β<sub>5</sub> Axis.

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Dataset Information

Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis.

Publications

Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin α<sub>v</sub>β<sub>5</sub> Axis.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin α_vβ₅ Axis.