Hierarchical stratification of the factors related to exertional dyspnoea and exercise intolerance in male COPD patients.

ABSTRACT:

Background

The order and extent of interactions across the factors affecting exertional dyspnoea (ED) and exercise intolerance (EI) in patients with chronic obstructive pulmonary disease (COPD) are not clear. We hypothesized that lung and non-lung variables were the primary variables, ED was the secondary variable and EI was the tertiary variable.

Methods

Data on demographics, blood tests, cardiac imaging, lung function tests and invasive dead space fractions (V_D/V_T) during incremental exercise test of 46 male COPD subjects were obtained. These variables were categorized by factor analysis and pair-wise correlation analysis was conducted. The best factor of each category was selected and then multivariate regression was conducted.

Results

Peak ti

SUBMITTER: Chuang ML 

PROVIDER: S-EPMC9629069 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature