Linoleic acid metabolism activation in macrophages promotes the clearing of intracellular Staphylococcus aureus.

ABSTRACT: Multidrug-resistant bacterial pathogens pose an increasing threat to human health. Certain bacteria, such as Staphylococcus aureus, are able to survive within professional phagocytes to escape the bactericidal effects of antibiotics and evade killing by immune cells, potentially leading to chronic or persistent infections. By investigating the macrophage response to S. aureus infection, we may devise a strategy to prime the innate immune system to eliminate the infected bacteria. Here we applied untargeted tandem mass spectrometry to characterize the lipidome alteration in S. aureus infected J774A.1 macrophage cells at multiple time points. Linoleic acid (LA) metabolism and sphingolipid metabolism pathways were found to be two major perturbed pathways upon S. aureus

SUBMITTER: Yan B 

PROVIDER: S-EPMC9629105 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature