A resistome survey across hundreds of freshwater bacterial communities reveals the impacts of veterinary and human antibiotics use.

ABSTRACT: Our decreasing ability to fight bacterial infections is a major health concern. It is arising due to the evolution of antimicrobial resistance (AMR) in response to the mis- and overuse of antibiotics in both human and veterinary medicine. Lakes integrate watershed processes and thus may act as receptors and reservoirs of antibiotic resistance genes (ARGs) introduced into the watershed by human activities. The resistome - the diversity of ARGs - under varying anthropogenic watershed pressures has been previously studied either focused on few select genes or few lakes. Here, we link the resistome of ~350 lakes sampled across Canada to human watershed activity, trophic status, as well as point sources of ARG pollution including wastewater treatment plants and hospitals in the watershed. A hig

SUBMITTER: Kraemer SA 

PROVIDER: S-EPMC9629221 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature