The role of comorbidities alongside patient and disease characteristics in long-term disease activity in RA using UK inception cohort data.

ABSTRACT:

Objectives

Control of disease activity in RA is a crucial part of its management to prevent long-term joint damage and disability. This study aimed to identify early predictors of poor disease activity at 5 and 10 years, focusing on comorbidities and clinical/sociodemographic factors at first presentation.

Methods

Patients from two UK-based RA cohorts were classified into two groups; low (<3.2) and moderate/high (≥3.2) DAS using 28 joint counts (DAS28) at 5/10 years. Clinical variables (e.g. rheumatoid nodules, erosions), sociodemographic factors (e.g. ethnicity, deprivation) and comorbidities were recorded at baseline and yearly thereafter. The Rheumatic Diseases Comorbidity Index quantified patient comorbidity burden. Binary logistic regression models (outcome low vs moder

SUBMITTER: Busby AD 

PROVIDER: S-EPMC9629371 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature