Factors correlating with survival following adjuvant or definitive radiosurgery for large brain metastases.

ABSTRACT:

Background

We sought to identify variates correlating with overall survival (OS) in patients treated with surgery (S) plus adjuvant stereotactic radiosurgery (SRS) versus definitive SRS for large (>4 cc) brain metastases (BrM).

Methods

We used univariate (UVA) and multivariate analyses (MVA) to identify survival correlates among eligible patients identified from a prospective registry and compared definitive SRS to S+ adjuvant SRS cohorts using propensity score-matched analysis (PSMA). Secondary outcomes were measured using the cumulative incidence (CI) method.

Results

We identified 364 patients; 127 and 237 were treated with S+SRS and definitive SRS, respectively. On UVA, SRS alone [HR1.73 (1.35,2.22) P < .001), BrM quantity [HR 1.13 (1.06-1.22) (P < .001)];

SUBMITTER: Gutierrez-Valencia E 

PROVIDER: S-EPMC9629433 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature