BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis.

ABSTRACT:

Background

The key oncogene B-cell lymphoma 6 (BCL6) drives malignant progression by promoting proliferation, overriding DNA damage checkpoints and blocking cell terminal differentiation. However, its functions in the placenta and the endometrium remain to be defined.

Objective and rationale

Recent studies provide evidence that BCL6 may play various roles in the human placenta and the endometrium. Deregulated BCL6 might be related to the pathogenesis of pre-eclampsia (PE) as well as endometriosis. In this narrative review, we aimed to summarize the current knowledge regarding the pathophysiological role of BCL6 in these two reproductive organs, discuss related molecular mechanisms, and underline associated research perspectives.

Search methods

We conducted a comprehen

SUBMITTER: Louwen F 

PROVIDER: S-EPMC9629482 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature