The rearing environment persistently modulates mouse phenotypes from the molecular to the behavioural level.

ABSTRACT: The phenotype of an organism results from its genotype and the influence of the environment throughout development. Even when using animals of the same genotype, independent studies may test animals of different phenotypes, resulting in poor replicability due to genotype-by-environment interactions. Thus, genetically defined strains of mice may respond differently to experimental treatments depending on their rearing environment. However, the extent of such phenotypic plasticity and its implications for the replicability of research findings have remained unknown. Here, we examined the extent to which common environmental differences between animal facilities modulate the phenotype of genetically homogeneous (inbred) mice. We conducted a comprehensive multicentre study, whereby inbred C57B

SUBMITTER: Jaric I 

PROVIDER: S-EPMC9629646 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature