Strength-dependent perturbation of whole-brain model working in different regimes reveals the role of fluctuations in brain dynamics.

ABSTRACT: Despite decades of research, there is still a lack of understanding of the role and generating mechanisms of the ubiquitous fluctuations and oscillations found in recordings of brain dynamics. Here, we used whole-brain computational models capable of presenting different dynamical regimes to reproduce empirical data's turbulence level. We showed that the model's fluctuations regime fitted to turbulence more faithfully reproduces the empirical functional connectivity compared to oscillatory and noise regimes. By applying global and local strength-dependent perturbations and subsequently measuring the responsiveness of the model, we revealed each regime's computational capacity demonstrating that brain dynamics is shifted towards fluctuations to provide much-needed flexibility. Importantly,

SUBMITTER: Sanz Perl Y 

PROVIDER: S-EPMC9629648 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature