Soluble urokinase-type plasminogen activator receptor improves early risk stratification in cardiogenic shock.

ABSTRACT:

Aims

Soluble urokinase-type plasminogen activator receptor (suPAR) is a biomarker reflecting the level of immune activation. It has been shown to have prognostic value in acute coronary syndrome and heart failure as well as in critical illness. Considering the complex pathophysiology of cardiogenic shock (CS), we hypothesized suPAR might have prognostic properties in CS as well. The aim of this study was to assess the kinetics and prognostic utility of suPAR in CS.

Methods and results

SuPAR levels were determined in serial plasma samples (0-96 h) from 161 CS patients in the prospective, observational, multicentre CardShock study. Kinetics of suPAR, its association with 90-day mortality, and additional value in risk-stratification were investigated. The median suPAR-level at

SUBMITTER: Hongisto M 

PROVIDER: S-EPMC9629697 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature