Predictive molecular biomarkers for determining neoadjuvant chemosensitivity in muscle invasive bladder cancer.

ABSTRACT:

Introduction

Identifying neoadjuvant chemotherapy (NAC) response in patients with muscle invasive bladder cancer (MIBC) has had limited success based on clinicopathological features and molecular subtyping. Identification of chemotherapy responsive cohorts would facilitate delivery to those most likely to benefit.

Objective

Develop a molecular signature that can identify MIBC NAC responders (R) and non-responders (NR) using a cohort of known NAC response phenotypes, and better understand differences in molecular pathways and subtype classifications between NAC R and NR.

Materials and methods

Presented are the messenger RNA (mRNA) and microRNA (miRNA) differential expression profiles from initial transurethral resection of bladder tumor (TURBT) specimens of a discovery

SUBMITTER: Murphy N 

PROVIDER: S-EPMC9629806 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature