Visual experience has opposing influences on the quality of stimulus representation in adult primary visual cortex.

ABSTRACT: Transient dark exposure, typically 7-10 days in duration, followed by light reintroduction is an emerging treatment for improving the restoration of vision in amblyopic subjects whose occlusion is removed in adulthood. Dark exposure initiates homeostatic mechanisms that together with light-induced changes in cellular signaling pathways result in the re-engagement of juvenile-like plasticity in the adult such that previously deprived inputs can gain cortical territory. It is possible that dark exposure itself degrades visual responses, and this could place constraints on the optimal duration of dark exposure treatment. To determine whether eight days of dark exposure has a lasting negative impact on responses to classic grating stimuli, neural activity was recorded before and after dark exp

SUBMITTER: Jeon BB 

PROVIDER: S-EPMC9629826 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature