Phenotypic characterization of regional human meniscus progenitor cells.

ABSTRACT: Stimulating meniscus regeneration using meniscal progenitor cells has been suggested as a promising new strategy. However, there is a lack of studies which decisively identify and characterize progenitor cell populations in human meniscus tissues. In this study, donor-matched progenitor cells were isolated via selective fibronectin adhesion from the avascular and vascular regions of the meniscus and chondroprogenitors from articular cartilage (n = 5). The mixed populations of cells from these regions were obtained by standard isolation techniques for comparison. The colony formation efficacy of avascular progenitors, vascular progenitors and chondroprogenitors was monitored using Cell-IQ^® live cell imaging. Proliferation rates of progenitors were compared with their mixed

SUBMITTER: Wang J 

PROVIDER: S-EPMC9629835 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature