Salivary microRNA profiling dysregulation in autism spectrum disorder: A pilot study.

ABSTRACT:

Introduction

Autism spectrum disorders (ASD) are the most prevalent neurobiological disorders in children. The etiology comprises genetic, epigenetic, and environmental factors such as dysfunction of the immune system. Epigenetic mechanisms are mainly represented by DNA methylation, histone modifications, and microRNAs (miRNA). The major explored epigenetic mechanism is mediated by miRNAs which target genes known to be involved in ASD pathogenesis. Salivary poly-omic RNA measurements have been associated with ASD and are helpful to differentiate ASD endophenotypes. This study aims to comprehensively examine miRNA expression in children with ASD and to reveal potential biomarkers and possible disease mechanisms so that they can be used to improve faction between individuals by promo

SUBMITTER: Kalemaj Z 

PROVIDER: S-EPMC9629840 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature