Cardiac myosin filaments are directly regulated by calcium

ABSTRACT: Calcium induces a structural transition of myosin heads from ordered off states close to the thick filament to disordered on states near the thin filaments associated with a biochemical shift from the super-relaxed state(s) to the disordered-relaxed state(s) of myosin. Classically, striated muscle contraction is initiated by calcium (Ca2+)-dependent structural changes in regulatory proteins on actin-containing thin filaments, which allow the binding of myosin motors to generate force. Additionally, dynamic switching between resting off and active on myosin states has been shown to regulate muscle contractility, a recently validated mechanism by novel myosin-targeted therapeutics. The molecular nature of this switching, however, is not understood. Here, using a combination of small-angle x-

SUBMITTER: Ma W 

PROVIDER: S-EPMC9629851 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature