Antitumor Effect of Low-Dose of Rapamycin in a Transgenic Mouse Model of Liver Cancer.

ABSTRACT:

Purpose

We investigate whether low-dose rapamycin is effective in preventing hepatocellular carcinoma (HCC) growth and treating HCC after tumor development in transgenic mice.

Materials and methods

We established transgenic mice with HCC induced by activated HrasG12V and p53 suppression. Transgenic mice were randomly assigned to five experimental groups: negative control, positive control, tacrolimus only, rapamycin only, and tacrolimus plus rapamycin. The mice were further divided into two groups according to time to commencement of immunosuppressant treatment: de novo treatment and post-tumor development.

Results

In the de novo treatment group, marked suppression of tumor growth was observed in the rapamycin only group. In the post-tumor development group, the rapam

SUBMITTER: Lee HS 

PROVIDER: S-EPMC9629903 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature