Dysregulated naive B cells and de novo autoreactivity in severe COVID-19.

ABSTRACT: Severe SARS-CoV-2 infection¹ has been associated with highly inflammatory immune activation since the earliest days of the COVID-19 pandemic^2-5. More recently, these responses have been associated with the emergence of self-reactive antibodies with pathologic potential^6-10, although their origins and resolution have remained unclear¹¹. Previously, we and others have identified extrafollicular B cell activation, a pathway associated with the formation of new autoreactive antibodies in chronic autoimmunity^12,13, as a dominant feature of severe and critical COVID-19 (refs. ^14-18). Here, using single-cell B cell repertoire analysis of patients with mild and severe disease, we identify the expansion of a naive-derived, low-mutati

SUBMITTER: Woodruff MC 

PROVIDER: S-EPMC9630115 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature