Design of amino acid- and carbohydrate-based anticancer drugs to inhibit polymerase η.

ABSTRACT: DNA polymerase η (polη) is of significant value for designing new families of anticancer drugs. This protein takes a role in many stages of the cell cycle, including DNA replication, translesion DNA synthesis, and the repairing process of DNA. According to many studies, a high level of expression of polη in most cases has been associated with low rates of patients' survival, regardless of considering the stage of tumor cells. Thus, the design of new drugs with fewer side effects to inhibit polη in cancerous cells has attracted attention in recent years. This project aims to design and explore the alternative inhibitors for polη, which are based on carbohydrates and amino acids. In terms of physicochemical properties, they are similar to the traditional anticancer drugs such as Cytarabine (

SUBMITTER: Kalhor S 

PROVIDER: S-EPMC9630280 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature