Brain cortical alterations in COVID-19 patients with neurological symptoms.

ABSTRACT:

Background

Growing evidence suggests that the central nervous system is affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), since infected patients suffer from acute and long-term neurological sequelae. Nevertheless, it is currently unknown whether the virus affects the brain cortex. The purpose of this study was to assess the cortical gray matter volume, the cortical thickness, and the cortical surface area in a group of SARS-CoV-2 infected patients with neurological symptoms compared to healthy control subjects. Additionally, we analyzed the cortical features and the association with inflammatory biomarkers in the cerebrospinal fluid (CSF) and plasma.

Materials and methods

Thirty-three patients were selected from a prospective cross-sectional study co

SUBMITTER: Sanabria-Diaz G 

PROVIDER: S-EPMC9630324 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature