Methylation-driven gene DLL3 is a potential prognostic biomarker in ocular melanoma correlating with metastasis.

ABSTRACT:

Background

Ocular melanoma is an aggressive malignancy with a high rate of metastasis and poor prognosis. Increasing evidence indicated that DNA methylation plays an important role in the occurrence and development of ocular melanoma. Hence, exploring new diagnostic and prognostic biomarkers at the genetic level may be beneficial to the prognosis of patients with ocular melanoma.

Methods

We collected DNA methylation and gene expression profiles of human UM (uveal melanoma) and CM (conjunctival melanoma) samples from various datasets. We conducted differential methylation and expression analyses to screen the potential biomarkers. Correlation analysis was performed to investigate the relationships between the expression level of DLL3 (delta-like protein 3) and the methylation

SUBMITTER: Yang L 

PROVIDER: S-EPMC9630341 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature