Emergence of a NDM-1-producing ST25 Klebsiella pneumoniae strain causing neonatal sepsis in China.

ABSTRACT: Carbapenem-resistant Klebsiella pneumoniae (CRKP) seriously threaten the efficacy of modern medicine with a high associated mortality rate and unprecedented transmission rate. In this study, we isolated a clinical K. pneumoniae strain DY1928 harboring bla _NDM-1 from a neonate with blood infection. Antimicrobial susceptibility testing indicated that DY1928 was resistant to various antimicrobial agents, including meropenem, imipenem, ceftriaxone, cefotaxime, ceftazidime, cefepime, piperacillin-tazobactam, and amoxicillin-clavulanate. S1 nuclease-pulsed field gel electrophoresis (S1-PFGE), southern blot and conjugation experiment revealed that the bla _NDM-1 gene was located on a conjugative plasmid of IncA/C2 type with a 147.9 kb length. Whole

SUBMITTER: Zhao J 

PROVIDER: S-EPMC9630351 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature