HRas and Myc synergistically induce cell cycle progression and apoptosis of murine cardiomyocytes.

ABSTRACT:

Aim

Adult mammalian cardiomyocytes are incapable of significant proliferation, limiting regeneration after myocardial injury. Overexpression of the transcription factor Myc has been shown to drive proliferation in the adult mouse heart, but only when combined with Cyclin T1. As constitutive HRas activity has been shown to stabilise Cyclin T1 in vivo, we aimed to establish whether Myc and HRas could also act cooperatively to induce proliferation in adult mammalian cardiomyocytes in vivo.

Methods and results

Using a genetically modified mouse model, we confirmed that constitutive HRas activity (HRas ^{G 12 V} ) increased Cyclin T1 expression. HRas ^{G 12 V} and constitutive My

SUBMITTER: Boikova A 

PROVIDER: S-EPMC9630352 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature