Context-dependent amygdala-prefrontal connectivity during the dot-probe task varies by irritability and attention bias to angry faces.

ABSTRACT: Irritability, defined as proneness to anger, is among the most common reasons youth are seen for psychiatric care. Youth with irritability demonstrate aberrant processing of anger-related stimuli; however, the neural mechanisms remain unknown. We applied a drift-diffusion model (DDM), a computational tool, to derive a latent behavioral metric of attentional bias to angry faces in youth with varying levels of irritability during functional magnetic resonance imaging (fMRI). We examined associations among irritability, task behavior using a DDM-based index for preferential allocation of attention to angry faces (i.e., extra-decisional time bias; Δt₀), and amygdala context-dependent connectivity during the dot-probe task. Our transdiagnostic sample, enriched for irritability, inclu

SUBMITTER: Naim R 

PROVIDER: S-EPMC9630440 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature