Erratic and blood vessel-guided migration of astrocyte progenitors in the cerebral cortex.

ABSTRACT: Astrocytes are one of the most abundant cell types in the mammalian brain. They play essential roles in synapse formation, maturation, and elimination. However, how astrocytes migrate into the gray matter to accomplish these processes is poorly understood. Here, we show that, by combinational analyses of in vitro and in vivo time-lapse observations and lineage traces, astrocyte progenitors move rapidly and irregularly within the developing cortex, which we call erratic migration. Astrocyte progenitors also adopt blood vessel-guided migration. These highly motile progenitors are generated in the restricted prenatal stages and differentiate into protoplasmic astrocytes in the gray matter, whereas postnatally generated progenitors do not move extensively and differentiate into fibrous astrocy

SUBMITTER: Tabata H 

PROVIDER: S-EPMC9630450 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature