Helicobacter pylori-infected human neutrophils exhibit impaired chemotaxis and a uropod retraction defect.

ABSTRACT: Helicobacter pylori is a major human pathogen that colonizes the gastric mucosa and plays a causative role in development of peptic ulcers and gastric cancer. Neutrophils are heavily infected with this organism in vivo and play a prominent role in tissue destruction and disease. Recently, we demonstrated that H. pylori exploits neutrophil plasticity as part of its virulence strategy eliciting N1-like subtype differentiation that is notable for profound nuclear hypersegmentation. We undertook this study to test the hypothesis that hypersegmentation may enhance neutrophil migratory capacity. However, EZ-TAXIScan™ video imaging revealed a previously unappreciated and progressive chemotaxis defect that was apparent prior to hypersegmentation onset. Cell speed and direction

SUBMITTER: Prichard A 

PROVIDER: S-EPMC9630475 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature