Radiotherapy delays malignant transformation and prolongs survival in patients with IDH-mutant gliomas.

ABSTRACT:

Objective

IDH-mutant lower-grade gliomas (LGGs, grade 2 or 3) eventually transform into secondary grade 4 astrocytomas (sA_IDHmut/G4). Here, we sought to describe the transformation time, risk factors, and outcomes in malignant transformation of IDH-mutant LGGs.

Methods

We screened data for 108 patients with sA_IDHmut/G4 in the Chinese Glioma Genome Atlas who had initial IDH-mutant LGGs and underwent reoperation during 2005-2021. We evaluated the transformation time from IDH-mutant LGGs to sA_IDHmut/G4, and associated risk factors and outcomes. Malignant transformation was defined as pathological confirmation of grade 4 astrocytoma.

Results

The median age of the 108 patients with IDH-mutant LGGs was 35 years (range, 19-54); the median age

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9630524 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature