Comprehensive analysis of cuproptosis-related genes and tumor microenvironment infiltration characterization in breast cancer.

ABSTRACT:

Background

Cuproptosis is a newly discovered programmed cell death dependent on overload copper-induced mitochondrial respiration dysregulation. The positive response to immunotherapy, one of the most important treatments for invasive breast cancer, depends on the dynamic balance between tumor cells and infiltrating lymphocytes in the tumor microenvironment (TME). However, cuproptosis-related genes (CRGs) in clinical prognosis, immune cell infiltration, and immunotherapy response remain unclear in breast cancer progression.

Methods

The expression and mutation patterns of 12 cuproptosis-related genes were systematically evaluated in the BRCA training group. Through unsupervised clustering analysis and developing a cuproptosis-related scoring system, we further explored the re

SUBMITTER: Song S 

PROVIDER: S-EPMC9630583 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature