Molecular profiling of core immune-escape genes highlights LCK as an immune-related prognostic biomarker in melanoma.

ABSTRACT: The tumor microenvironment is complicated and continuously evolving. This study was devoted to the identification of potential prognostic biomarkers based on the tumor microenvironment associated with immunotherapy for melanoma. This study integrates a couple of melanoma single cell and transcriptome sequencing datasets and performs a series of silico analyses as nicely as validation of molecular biology techniques. A core set of immune escape related genes was identified through Lawson et al. and the ImmPort portal. The differential proteins were identified through the cBioPortal database. Regression analysis was used to profile independent prognostic factors. Correlation with the level of immune cell infiltration was evaluated by multiple algorithms. The capacity of LCK to predict respon

SUBMITTER: Wang F 

PROVIDER: S-EPMC9630653 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature